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Clear Skincare’s B3 Serum contains 5% Niacinamide in a 1% hyaluronic acid serum. It is particularly good for anyone with red or inflamed skin and for those with sun damage.

Niacinamide, also also known as vitamin B3, is well recognised as an essential nutrient when it comes to a well-functioning and healthy body. The digestive system, nervous system and brain function are all dependent on having adequate B3.

Our daily supply comes from red meat, chicken, turkey and fish like salmon and tuna as well as green leafy vegetables, tomatoes and asparagus and many packaged foods are fortified with Niacin, so deficiency is rare.

Niacinamide Serum has been found to have the following benefits:

  • Have anti-inflammatory properties, which may be used for the treatment of bullous (blistering) diseases.
  • Effectively treat acne by its anti-inflammatory action and reducing sebum.
  • Improve skin barrier function through decreasing water loss through the epidermis (the outer skin layer) thus increasing skin hydration.
  • Improve the complexion, by improving the pigmentation, blotchiness and redness of ageing skin; it is used in a number of cosmeceutical products.
  • Reduce actinic keratoses and possibly reduce the risk of skin cancer.


How To Use:

Apply 2-3 drops on face, neck and chest, 1-2 times daily.


How It Works:

In multiple clinical studies, topical nicotinamide improved fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing) as well as elasticity. One study showed nicotinamide to increase the skin's production of ceramides, which are natural emollients and skin protectants, thus improving skin hydration.

A double-blind, placebo-controlled, split-face, left-right, randomised 12-week study in 50 women evaluated the effects of 5% topical nicotinamide on various signs of skin aging. The researchers reported topical nicotinamide resulted in significant improvement in fine lines/wrinkles, pigmentation, texture and red blotchiness.

Another study of 30 healthy Japanese females reported improvement of eyelid wrinkles after 8 weeks of application of a cosmetic containing 4% nicotinamide.

Ultraviolet radiation (UVR) is a major risk factor for skin cancer development. The mechanisms by which UVR leads to cancer are complex including direct damage to DNA and effects on the immune system. Nicotinamide has been shown to enhance the repair of direct and oxidative DNA damage in human keratinocytes and in human skin.

In a randomised controlled clinical trial in 50 patients, 1% nicotinamide gel applied twice daily to the head, forearms and hands for 6 months reduced the mean number of precancerous actinic keratoses by 28%. Another study has shown that oral nicotinamide also reduces the numbers of actinic keratoses compared to placebo. A reduction in skin cancers has also been observed in high-risk sun-damaged patients treated with nicotinamide.

The clinical signs and symptoms of rosacea include increased facial skin dryness, redness and sensitivity. In at least two studies, moisturisers containing nicotinamide have been shown to improve skin barrier function in rosacea patients, leading to diminished reaction to irritants including cleansers and cosmetics.

Nicotinamide, available in topical cream, gel and oral forms has been shown to be effective in clearing acne. In a controlled clinical trial, 4% nicotinamide gel was found to be as effective as the topical antibiotic 1% clindamycin gel in the treatment of acne vulgaris in 76 patients with moderate acne. The study concluded that the anti-inflammatory properties of nicotinamide may have contributed towards its success in acne.

Nicotinamide also reduces facial sebum production. Sebum is responsible for facial shine and contributes to noninflamed comedones and inflammatory acne lesions. Results of a well-controlled clinical trial in Caucasian and Japanese women have shown that application of 2% nicotinamide moisturiser to the face for 4-6 weeks reduces sebum production with significant differences in facial shine and oiliness.



Results are visible within 1-2 weeks of use.



Before - Lines and wrinkles


After - Lines and wrinkles